4/16/2024 0 Comments Bondage gagging![]() ![]() Large Size: Bondage Boutique XL If you’re on the more well-endowed side, buy the Bondage Boutique XL O-Ring Gag. Not least of which is that it is handmade by a leading supplier of high-quality BDSM toys and is remarkably and pleasurably versatile. Versatile: Stockroom O-ring Gag The many ring choices make Stockroom’s O-Ring Gag excellent for beginners and advanced BDSM players alike. With a flexible silicone covering, adjustable strap, ideally-sized hole, and affordable price, it’s obvious why I selected this product for our number one spot.
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![]() I Will Teach You How To Play Chess – Openings (Beginners) (Skillshare)įor those that are looking to learn the best openings in chess such as the Queen’s Gambit, Ruy Lopez, Bishop’s Opening, or the Blackmar Diemer Gambit, this is the class for you! Taught by highly rated chess instructor. ![]() Overall, a great course for those who have some prior experience in the game. With all Udemy courses, students get lifetime access to course content, certificate of completion, and access to desktop/ mobile video lessons. There are also extra class modules of setting up the board, special moves, how to castle, double attack, pins, skewers, pawn promotion, mating various pieces, and ends with a quiz. During this time, he has helped 3,000 students to better understand the game of chess.ĭuring the 2.5-hour training, you will become familiar with chess basics, how to open properly, strengthen your middle game, and how to close out games with a checkmate. Robert Gummerlock is your instructor for the course, who has been a player of the game for decades and has become a teacher in the past 3 years for kids and adults. Moving onto my next pick is a great lesson for beginners and intermediate-level players who want to strengthen their game, have a deeper understanding of chess tactics, and develop strategic thinking. Once completed, students can then move on to playing AI chess games which vary for all skill levels.Īgain, being hosted on Skillshare, new users can take this class, plus all the other chess lessons on this list for free when utilizing their 1-month free trial!įREE Skillshare Trial 4. In total, this 1-hour beginner level class is split up into 11 micro lessons which include setting up the board, basics of the king, queen, rooks, knights, bishops, castle, and pawns. Taught by internet business guru and creative professional Sergey Kasimov, this class is designed to bring you into the game of chess for the first time which is broken down step-by-step. If you have never played chess before and don’t even know how to set up the board, this is a great place to start! Next on my list is another great chess class that is aimed at complete beginners that want to get familiar with the board, the pieces, and the game itself. Chess 101: Learn how to play chess for newbies (Skillshare) Overall, a great course!Īctivate FREE Skillshare Trial 3. There are also 12 included chess puzzles to solve and an explanation of the solutions.īeing hosted on Skillshare, new users can take this chess class for free when taking advantage of their 1-month free trial! Users can also take all lessons at their own pace and across multiple devices. Video lessons cover the board and pieces, in-depth looks at the king, queen, bishop, rook, knight, and pawn, plus specialty moves such as pawn promotion, en passant, and castling, and even how to play to a draw. Taught by enthusiast chess player Arne Kähler who has years of experience in playing strategic chess, he will guide you through this 3-hour class which is engaging and surprisingly quite fun! If you feel like you never have the time to learn chess, this course will show you how to make the game less complicated and more fun, plus give you the knowledge of how to win consistently. I Will Teach You How To Play Chess! (Skillshare) Taught by world champion Garry Kasparov. ![]() You will also receive a detailed workbook, a periodic newsletter, and access to a large online community of teachers and students. In total, there are over 7 hours of on-demand videos separated into 29 individual modules that include an introduction to the fundamentals of chess, double attacks, pins, winning trades, interference, openings, end games, using computers, and several case studies of actual games.Ĭourses from MasterClass online learning platform are accessible across multiple platforms, including phones, tablets, computers, and TV. Since that time, he has won six total championships, surpassed Bobby Fischer’s peak rating, and developed a skill and mastery of the game like few people have in history. Your instructor for this class is multiple-time world chess champion player Garry Kasparov, who at the age of 22 became the youngest ever to win the world championship in chess. You will learn insights into the game that will help develop your own skills and lead you to a better understanding of chess.
4/16/2024 0 Comments Pleurisy lung sounds![]() Our research group in collaboration with Shuichi Takayama, a former U-M professor of biomedical engineering now at Georgia Tech, has done that for crackles in microfluidic platforms, but that is just a beginning. It’s a paradigm shift for a field that has a 200-year history with the stethoscope.Įxperimental models need to be designed to include measurement of injury, from cellular to whole organ level, along with measurement of sound. Since no one has ever viewed lung sounds as a cause of disease, they have not been investigating it. Grotberg: Well, this is completely new territory. How do you see this new understanding impacting diagnoses or treatments? The sequence is very damaging to the cells, and again they respond with inflammation and injury. The gurgling is a mixture of liquid and air with popping bubbles, just like a fluid-overloaded lung. The sound mechanism is very similar to drinking through a straw when you get down to the last sips at the bottom of the cup. Grotberg: Crackles are ruptures of liquid plugs in the smaller airway tubes that pop open during inspiration. Asthma already involves inflammation of the airway tubes in the lung, so wheezing likely just makes things worse.Īnd what’s going on when patients inhale and produce a crackling sound? Grotberg: Vibrating the lung cells makes them promote inflammation which damages the lung. ![]() The pitch you hear is the frequency of oscillation of the balloon material, which for a lung would be the airway tube made of cells. An asthmatic lung airway is similar because it is constricted to a small narrow passageway. Grotberg: Wheezing is very much like the sound from a deflating balloon when you make it squeal by stretching the outlet. ![]() What exactly is happening when a sick patient wheezes as they exhale? That is a 180-degree thought reversal from interpreting them as only a “sign” of disease.īreak this down for us a bit more. We’ve seen evidence of this in our experiments. So wheezes and crackles actually “cause” disease. The cells respond with inflammation, which, itself, is a disease. They make the sound, and that mechanical event is also pounding away on the lung tissue. The physical mechanisms that cause wheezing and crackling, while smaller forces than a cough, are similar. Ouch!Īs an extreme example, the loudest sound a lung generates is a severe cough, which can cause, in rare instances, a pneumothorax (ruptured lung), i.e. If you clap hard enough, your hands will hurt. Grotberg: Well, for a sound to be created, a mechanical event must occur, like clapping your hands. You’ve found that sounds could represent more than just the presence of a disease. Pulmonary edema is a common example, often a byproduct of heart failure. Crackles, on the other hand, are only heard by a stethoscope and are a sign of too much fluid in the lung. Patients who wheeze can be so loud you can hear it standing next to them. Grotberg: Typically, wheezing is found in asthma and emphysema. These wheezes and crackles are signs of what diseases? There are normal sounds of air movement, but also there can be abnormal sounds, like wheezes during expiration (breathing out) and crackles during inspiration (breathing in). For the lungs, typically the patient is asked to breathe in and out deeply. Grotberg: Two important organs being monitored are the heart and the lungs. When doctors pull out a stethoscope, what are they listening for? He answered some questions about the research. And they represent a paradigm shift for how doctors understand what they hear through a stethoscope. The findings could eventually change how lung diseases are treated, he says. Exploring this in humans is a research goal. His conclusion is based on evidence from experiments on microfluidic chips and on animal models. James Grotberg, professor of biomedical engineering at the College of Engineering and professor of surgery at the Medical School, recently published a study describing how the mechanics that produce those noises with every breath are likely a cause of injury and inflammation. 4/16/2024 0 Comments Static equilibrium 3d problemsPractically, a structure is called 'statically overdetermined' when it comprises more mechanical constraints – like walls, columns or bolts – than absolutely necessary for stability. Numerically, this can be achieved by using matrix structural analyses, finite element method (FEM) or the moment distribution method ( Hardy Cross). Mathematically, this requires a stiffness matrix to have full rank.Ī statically indeterminate structure can only be analyzed by including further information like material properties and deflections. It indicates the possibility of self-stress (stress in the absence of an external load) that may be induced by mechanical or thermal action. This page provides a set of links to notes (with example problems) and equation sheets in elementary statics (often referred to as engineering mechanics. Equilibrium of a Rigid Body in Three Dimensions. Statical indeterminacy, however, is the existence of a non-trivial (non-zero) solution to the homogeneous system of equilibrium equations. For static equilibrium, the sum of moments about A must be zero. internal forces in equilibrium with zero external loads are not possible. The structure has no possible states of self-stress, i.e. Statical determinacy ĭescriptively, a statically determinate structure can be defined as a structure where, if it is possible to find internal actions in equilibrium with external loads, those internal actions are unique. However, it is not possible to satisfy the horizontal force equation unless F h = 0. The solution yields the same results as previously obtained. Todays Objectives: Students will be able to solve 3-D particle equilibrium problems by a) Drawing a 3-D free body diagram, and. There are 3 equations for 2d and 4 equations for 3d: Rigid Body-Two Dimensions. Now for a rigid body where forces are analyzed at different points on a body, we can take moments into account. ![]() In this case, the two unknowns V A and V C can be determined by resolving the vertical force equation and the moment equation simultaneously. The particle equilibrium equations were covered in section 2.3. ![]() In order to distinguish between this and the situation when a system under equilibrium is perturbed and becomes unstable, it is preferable to use the phrase partly constrained here. If, in addition, the support at A is changed to a roller support, the number of reactions are reduced to three (without H A), but the beam can now be moved horizontally the system becomes unstable or partly constrained-a mechanism rather than a structure. Mathematics īased on Newton's laws of motion, the equilibrium equations available for a two-dimensional body are: ∑ F = 0 : ![]() In statics and structural mechanics, a structure is statically indeterminate when the static equilibrium equations – force and moment equilibrium conditions – are insufficient for determining the internal forces and reactions on that structure. To find the magnitude of the forces we resolve both vertically and horizontally.When a structure's static equilibrium equations have no unique solution Three-dimensional systems are closer to reality than two-dimensional systems and the basic principles to solving both are the same, however they are generally harder solve because of the additional degrees of freedom involved and the difficulty visualizing and determining distances, forces and moments in three dimensions. 4/16/2024 0 Comments Solitaire tripeaks freeIn this Tripeaks Solitaire online, you only have to click on the stock pile to turn a card. When this happens, you can take one or several cards from the stock pile to replace the one on the discard pile. If there is no card on the tableau to be put over the last discarded one, the sequence stops. In reality, rather than just creating pairs, you are expected to build sequences by going higher or lower with each move. The last card you add to the discard pile remains on top of it, facing forward, and becomes the next base for the following pairing. The color and the suits are irrelevant in a game of Tripeaks Solitaire. For instance, if your base card is a 5, you can pair it with either a 4 or a 6. You must pair it with a facing-forward card from the pyramids that is one point higher or lower than it. That card will serve as the first base to start deconstructing the pyramids. To start the game, we remove one card from the stock pile and position it facing up on the discard pile (that starts empty). The discard pile is where the players must put the collected cards. The remaining cards are grouped facing down in the stock pile. It is only possible to turn a card around when there is no overlapping with others. The cards on the bottom row (the base of each pyramid) are facing up, while the remaining ones are facing down. This means that, in total, you have 28 cards laid out in 4 rows. Each one has 4 cards for a base and ends with one single card as the peak. On the tableau, you will find three pyramids. In Tripeaks Solitaire, the board is divided into three main areas: the pyramids (on the tableau), the stock pile, and the discard pile. The cards can only be collected if they rank one point higher or lower than the top card on the discard pile. The goal is to collect all the cards displayed in the tableau by deconstructing the pyramids. ![]() Instead of creating complete sequences in order and by suit, the players now have to create mixed sequences alternating between cards one number higher and/or lower than the previous one. However, the way to do it is significantly different from that of Klondike or Spider Solitaire. These are positioned in such a way that they create three pyramids of overlapping cards, and since each pyramid has a peak, we have Tri-Peaks or triple peaks.Īs with other Solitaire games, the goal here is also to clear all the cards from the tableau. Its name comes from the shape of the cards displayed in the tableau. ![]() Tripeaks Solitaire is a single-player card game with an easy, but no less challenging, gameplay. 4/15/2024 0 Comments What mutation causes SCIDS![]() Gene therapy used for SCID-X1 clinical trials so far has been based on the use of retroviral vectors to transfer a corrective copy of the defective gene to autologous hematopoietic stem and progenitor cells (HSPCs), and was successfully performed for the first time more than 20 years ago ( 6). Gene therapy employs the introduction of DNA or RNA into target cells by adding a correct version of the gene (additive gene therapy) or more precisely correcting the defective gene or targeting the transgene to desirable genomic sites (gene editing) ( 5). Nowadays there are two possible therapeutic approaches for the restoration of the immune system in SCID-X1 patients: 1) hematopoietic stem cell transplantation (HSCT) and 2) autologous gene therapy ( 4). Due to severe immune defects and the ensuing occurrence of life-threatening infections, SCID-X1 is usually lethal in the first year of life unless definitive immune reconstitution is achieved. The most common form of SCID in Western geographies is X-linked SCID (SCID-X1), which accounts for ≈25–40% of all diagnosed SCIDs ( 2, 3). ![]() These immune alterations are caused by a monogenic defect, with up to eighteen different genes identified so far ( 1). SCID patients are characterized by a profound defect in the number or function of T-cells, which are associated to a variable extent with abnormalities in B and NK cell populations. Severe combined immunodeficiency diseases (SCIDs) are a group of life-threatening and rare primary immunodeficiencies, with an overall estimated incidence of ≈1:50,000 live births. This review provides an overview about the different gene therapy approaches used over the last 20 years to treat SCID-X1 patients, particularly focusing on lymphoid immune reconstitution, as well as the developments that have improved the process and outcomes. The most recent clinical trials using lentiviral vectors together with a low-dose pre-conditioning regimen have demonstrated excellent sustained T cell recovery, but also B and NK cells, in both children and adults. Consequently, considerable efforts have been made to develop safer vectors. ![]() However, some infants developed T-cell acute lymphoblastic leukemia after the gene therapy, due to vector-mediated insertional mutagenesis. The results were highly promising in SCID-X1 infants, showing long-term T-cell recovery and clinical benefit, although NK and B cell recovery was less robust. Gene therapy has been developed as an alternative treatment initially using γ-retroviral vectors to correct the defective γ chain in the absence of pre-conditioning treatment. However, when alternative donors are used, the success and survival rates are often lower. The treatment of choice for these patients is hematopoietic stem cell transplantation, with an excellent survival rate (>90%) if an HLA-matched sibling donor is available. Without any treatment the disease is usually lethal during the first year of life. The genetic origin is a defect in the interleukin 2 receptor γ chain ( IL2RG) gene and patients are classically characterized by absence of T and NK cells, as well as presence of partially-functional B cells. X-linked severe immunodeficiency disease (SCID-X1) is an inherited, rare, and life-threating disease.
4/15/2024 0 Comments Create online signature for pdf![]() ![]() Step 1: First of all, the user will access the online eSign feature and then choose the file that is required to be signed. The procedure to sign a document is well-explained as follows. Apart from this, it enables the user to insert already created signatures into the PDF file.Ĭertain steps are needed to be followed to sign the document. With the help of this feature, the user can create signatures using the online console of CocoDoc. Other than this, it can also be used as an online signature generator. The user can create, merge, split, convert and edit any PDF file. CocoDoc is recognized by different brands like TechTimes, Phandroid, and TechRadar. Its vast number of tools have been designed by keeping in mind the requirement of different kinds of users. It comes with a huge number of different features that are utilized by people. CocoDocĬocoDoc is a remarkable PDF editor. In this article, the reader will learn about different editing apps that are used as a signature generator. These apps are very useful in the business world because signing different documents is included in everyday work. Online e-sign apps are considered a blessing in disguise. To end this trouble, electronic signing applications were designed so that people could get the signatures easily by staying at their place. This was quite a prolonged procedure, and sometimes essential documents used to get lost during the sending and receiving process. In earlier ages, people used to travel to others or send documents through courier to get their signatures. 10 Best Signature Makers to Create Digital Signature Online 4/15/2024 0 Comments Matching foosball air hockey table![]() It turns any child's bedroom into their own personal game room! ![]() Lightweight and portable, just place it on a table and play away! When it's not in use, simply put it away and slip it under the bed or pop it in the cupboard!Ī great way to introduce children to the fun of air hockey. Pucks glide across the playing rink on a cushion of air for fast, exciting table hockey action. This terrific tabletop version of hockey looks, feels, sounds and plays just like the real thing. Users: Safety tested and appropriate for ages 3+. A durable and long-lasting product that can be used for many activities. Material: made from high-quality wood, which is lightweight, and safe for kids. Realistic Designed These mini Supreme triple game sets are made with great wood and are the miniature version of the life-size tables. Great for developing kid's fine motor skills, and hand-eye coordination, while teaching good sportsmanship, and fair play. Includes two billiard cues, a set of billiard balls, a triangle, and chalk Side ball return allows for easier ball retrieval, similar to pub-style billiards tables Play it on the go at family get-togethers, bars, camping trips, backyard fun, and more.Ĭompact size enables easy storage and portability for condensed fun anywhere with a table or flat surface ![]() ![]() On the table for yourself or gift it to friends and family for birthdays, Christmas, and other holidays. This product features everything you've come to expect from a full-size pool table. It comes with one miniaturized version of a pool table with felt tablecloth lining so you can play pool anywhere, anytime. Low on space, short on time? Play pool anywhere you go! This tabletop set includes everything the big tables have 16 solid resin billiard balls, two actual wood pool cues, a triangle rack for tight racks, and even a cube of chalk for extra ball control. This Supreme triple game set brings the action and excitement of aerodynamic hockey, foosball and pool to your home. So Whether your affinity is for foosball or air hockey or pool, this Supreme triple-game set will make your home the talk of the block. With 3 individual games, everyone can join in, as it creates a combined space where you can enjoy 3 of the best activities at the same time.Įasy hours of aerodynamic hockey or foosball or pool play! Ideal for any gathering. Perfectly Mixed and matched for a playful variety! Why not host your very own game evening quickly and easily with your own Mini Air Hockey Table, Mini Foosball table and Mini Pool Table? This Combination Supreme Triple Game Set will instantly turn any Room Into an instant Gameroom. Tornado Scottsdale Handcrafted Foosball Table $4,195.Calling all foosball enthusiasts, pool sharks, air hockey fans and game collectors!.Multiple finishes available Assembled Dimensions:.Doubled sided High Pressure Laminate Playfield.Oversized Split bushings with eco friendly ABS Plastic.Don’t miss out on your chance to have a beautiful, matching game room set right in your home. This Foosball table can match in finish with any Rustic pool or shuffleboard table. With three goalies to protect your team, you’ll spend countless hours in competition with friends and family. Description Combining the texture and style of the Rustic Series with the fun and exciting game of Foosball, the Barren Foosball table adds fun and variety to any home or game room. The main reason why most of these software are free is that it helps to promote the growth of software companies by providing a valuable service at absolutely no cost. These software are great and give better visual quality to your monitor along with providing better ease of control to the user. Most of the programs like Brightcut, F.lux and many more are free software that you get for free from the internet. To use F.lux on your PC, first download F.lux and then install it onto your PC using your windows installer CD/DVD.Īpart from making your computer screen brighter, the other benefit of installing Dimmer is that, it also reduces the chances of eye strain and fatigue due to prolonged watching of the same video on your monitor or TV. This tool has an advanced user interface which allows you to easily control the brightness and the dimness of your PC s monitor. F.lux is a simple and easy to use tool that automatically modifies the brightness of your windows based on the humidity and temperature around your PC. ![]() If you are tired of your dull computer screen then it is high time that you install F.lux on your PC and make it look amazing. Dimmer comes with a long list of over 45 useful and beautiful effects which enable you to easily change the screen brightness from anywhere in the world. This will prompt the pop-up menu to appear. Its the logo with a black background and a letter P on it. Once you download the program, you will automatically find it in your screen’s System Tray. To use Dimmer, you should first download Dimmer free from the internet and then install the software on your PC. Pangobright is a simple tool you can use to prevent bright, garish screens from affecting your surroundings or your vision. ![]() Dimmer is a simple tool that enables you to easily adjust the screen brightness of your PC s monitor from anywhere in the world. Dimmer is a very useful tool's program that you are running into your Windows PC for changing the brightness of your screen automatically. 4/15/2024 0 Comments Em dash persona poemsRhyme schemes can be much more complicated than this, and there are also such things as slant rhymes and internal rhymes. Here’s an example of that rhyme scheme, from the poem “ A Psalm of Life” by Henry Wadsworth Longfellow: A simple rhyme scheme is an “ABAB” rhyme scheme, in which the 1st line rhymes with the 3rd, and the 2nd line rhymes with the fourth. Free Verse Poetry Does Not Have: Rhyme SchemeĪ rhyme scheme is a pattern of rhyming words, typically at the end of each line of poetry. Other metrical patterns include the trochee, anapest, and dactyl. Each line, also, will usually include the same number of iambs. This pattern of unstressed-stressed is called an iamb in an iambic poem, a line of poetry roughly follows this pattern, word after word and line after line. Take, for example, the word “bombard.” Here, the second syllable is stressed, because you put emphasis on the word like this: “bom A syllable can be either stressed or unstressed, depending on how each syllable is emphasized. Meter refers to the pattern of syllabic stress in the poem. When discussing form in poetry, there are a few different concepts to know: Free Verse Poetry Does Not Have: Meter But first, if you don’t know what form, meter, or rhyme are, read below.Ĭharacteristics of free verse poetry include a lack of form, meter, and rhyme scheme. Characteristics of free verse poetry include a lack of form, meter, and rhyme scheme, which we will expand upon shortly. Before we look at a free verse poem definition, it’s important to understand what free verse poems aren’t. |
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